the next single is can't hold us, which is going to be insane. disappointed he's not shooting the video in seattle, but nonetheless it's a great song. i can definitely see it being as successful as thrift shop.
Interesting. Can't Hold Us is probably the most similar to Thrift Shop (both are pretty much just good natured fun songs that lack the deeper meaning of the stuff like Starting Over or Wing$ that pack a deeper punch). So it probably has the best shot at being another hit, but at the same time I feel like you can listen to those two songs and completely miss a large part of what Macklemore is really about.
I personally would've gone with Make The Money. That at least has a better message, while remaining hit ready. It'll probably be the third one if they choose to have a third single.