DMB will always be an epic band to me. This is a great song, and the video is so cracked-out and unique that I can't help but like it. While I love "Big Whiskey", I do hate the underlying sadness of the album due to circumstance.
I don't read the underlying themes as sad. I feel it more celebrates what LeRoi meant, and tries to convey more of a sense of appreciating life and not worrying about stupid things that don't really matter. More of showing what you should be focused on (your life and the ones you love) than everything else (politics, society, what other people thing).